Investigation of Thyroid Hormones and Prolactin Levels in Fertile and Infertile Women

Authors : Arzu Şahin, Feyyaz Önder

Pages : 1-6

Doi:10.19127/mbsjohs.63680

View : 19 | Download : 18

Publication Date : 2016-04-27

Article Type : Research

Abstract :Objective: This study was conducted to investigate thyroid hormones and prolactin levels in fertile and infertile women. Materials and Methods: The study enrolled a total of 84 women, 40 infertile and 44 fertile, aged between 15-45 years and applied to Kars Maternity and Child Hospital, Obstetrics Clinic and Artvin State Hospital, Obstetrics and Gynecology Clinic. The study population was divided into 3 groups: Group P (n=30, women having primary infertility), Group S (n=10, women having secondary infertility) and Group F (N=44, fertile women). Blood samples were obtained in early follicular phase and serum thyrotropin (TSH), free triiodothyronine (FT 3) , free thyroxine (FT 4 ) and prolactin levels were determined by Microparticle Enzyme Immunoasay (MEIA) method. Results: Serum TSH levels were 1.70±0.40, 1.60±0.20 and 0.80±0.20 µIU/ml for the groups F, P and S, respectively (p> 0.05).  FT 3 levels were 2.36±0.06, 2.46±0.09 and 2.35±0.2 pg/ml while FT 4 levels were 0.98±0.02, 0.94±0.04 and 1.00±0.03 ng/dl for the groups F, P and S, respectively. There was a significant negative correlation between TSH and FT 4 (p=0.012, r = -0.275) and a significant positive correlation between FT 3 and FT 4 (p=0.002, r = 0.330). Serum prolactin levels were measured as 16.70±2.60, 21.10± 2.10 and 16.00±1.90 ng/ml respectively for the groups F, P and S and no significant difference was detected between the groups with respect to prolactin levels (p >0.05). Conclusion: As a result, there was no difference between the groups in terms of TSH, FT 3 , FT 4 and prolactin levels. Hormone levels were generally within normal limits and therefore we determine no significant relationship between infertility and investigated parameters in this study.
Keywords : TSH, FT3, FT4, Prolactin, Infertility, Fertilty