Mean platelet volume can predict subsequent Candida spp. airway colonization in mechanically ventilated subjects

Authors : Gülseren Yilmaz

Pages : 50-55

View : 30 | Download : 12

Publication Date : 2020-06-30

Article Type : Research

Abstract :Background: Despite the association between the airway colonization with Candida spp and impaired ICU outcomes of critically ill patients, little is known whether Candida colonization in respiratory tracts could be predicted with simple blood tests. The present study aims to investigate whether admission blood tests could provide information regarding the further Candida spp airway colonization in patients admitted to the ICU for MV. Materials and Methods: A hundred patients who were admitted to the ICU of our institute for invasive MV for more than 4 days were enrolled in this retrospective study. Venous blood samples were drawn upon admission for measurement complete blood count, procalcitonin, and C-reactive protein (CRP). Endotracheal aspirates were also obtained by 7 days intervals to identify Candida spp. airway colonization. Rapid assimilation or agglutination tests and API 20C AUX were performed for the identification of Candida spp. Results: Mean platelet volume was significantly higher in subjects who developed Candida spp. airway colonization compared to subjects without Candida spp. airway colonization during the ICU stay (10.5 ± 1.3 fl vs. 9.4 ± 1.4 fl, p <0. 001). Logistic regression analysis revealed that among the parameters studied, only MPV was a significant predictor for the development of Candida spp. airway colonization during the ICU stay (OR: 1.992, 95%CI: 1.289-3.078, p= 0.002). Conclusions: Mean platelet volume, a simple and readily available marker of the inflammatory state, can be used in the prediction of the subsequent Candida spp. airway colonization in mechanically ventilated subjects.
Keywords : airway colonization, candida, mean platelet volume