Does C-Reactive Protein, Mean Platelet Volume and Red Cell Distribution Width Predict Ventilator-Associated Events in Mechanically Ventilated Patients?

Authors : Esra Diyeke

Pages : 73-81

View : 30 | Download : 11

Publication Date : 2020-06-30

Article Type : Research

Abstract :Background: To investigate the role of C-reactive protein, procalcitonin, mean platelet volume (MPV), red cell distribution width (RDW), neutrophil–lymphocyte ratio (NLR) and other parameters of complete blood count on predictive value in patients with ventilator association events (VAE). Material and Methods: Seventy-six patients admitted to the intensive care unit of our institute -a tertiary center- with required mechanical ventilation between March 2019 and July 2019 were retrospectively recruited in the study. Demographic and clinical data including age, gender and laboratory test results were retrospectively collected from medical records and electronic databases. The study population was divided into two groups according to the development of VAE as VAE group or non-VAE group. Results: Twenty-nine subjects developed of VAE during the in hospital course (VAE group) and 47 subjects didn’t develop of VAE (non-VAE group). MPV, RDW, NLR, CRP and procalcitonin were significantly higher in the VAE group compared to that of the non-VAE group. Multiple logistic regression revealed that CRP, MPV and RDW were independent predictors of development of VAE in patients with mechanical ventilated. ROC curve analysis indicated a cut-off value 8.46 mg/dL for CRP (sensitivity 76%, specificity 74%), a cut-off value of 9.35 fl for MPV (sensitivity 69%, specificity 70%) and a cut-off value of 14.80 % for RDW (sensitivity 59%, specificity 58%) to predict development of VAE in patients with mechanical ventilated . Conclusion: CRP, acute phase reactant, MPV, as an emerging indicator of preexisting inflammation, and RDW, indicative of systemic inflammation might have predictive diagnostic value invivo of VAE. 
Keywords : Ventilator-association events, mean platelet volume