Cardiovascular risk factors in polycystic ovary syndrome; the relationship of dyslipidemia and obesity

Authors : Şefik Gökçe, Dilşad Herkiloğlu

Pages : 526-531

Doi:10.32322/jhsm.901791

View : 18 | Download : 10

Publication Date : 2021-09-05

Article Type : Research

Abstract :Aim: The abnormal endocrinological picture that occurs in polycystic ovary syndrome (PCOS) has been shown to affect many systems and can lead to a wide variety of complications. In our study, it was aimed to examine hormone levels, obesity, serum lipid levels and hematological parameters in adult women with PCOS. Material and Methods: The present study included 62 patients diagnosed with PCOS and 45 healthy women. Demographic data and laboratory results of all women were collected them from hospital automation system records and were analyzed. Results: The mean body mass index (BMI) (p=0.041), total cholesterol (p=0.038), triglyceride (p=0.022) and very low density lipoprotein (VLDL) cholesterol (p=0.003) levels in the patient group were significantly higher than the control group. In the patient group, anti-Müllerian hormon (AMH) (p<0.001), total testosterone (p<0.001) and free testosterone (p<0.001) were significantly higher than the control group, and follicle-stimulating hormon (FSH) was significantly lower (p<0.001). The rate of women (57.6%) with BMI value ≥25 kg/m2 in the patient group was significantly higher than the control group (35.6%) (p=0.026). In addition, having a BMI value of ≥25 kg/m2 had 2.47-fold (odds ratio; 1.11-5.48) higher risk for PCOS development. Conclusion: In our study, it was concluded that obesity plays a role in the development of PCOS, that the level of AMH in PCOS patients increases significantly enough to gain a diagnostic value, that a significant dyslipidemia develops in PCOS, and this might be a risk for the development of cardiovascular disease in the future.
Keywords : Polycystic ovarian syndrome (PCOS), anti-Mullerian hormone, body mass index, dyslipidemia, cholesterol.