Is mean platelet volume better than other long-used non-invasive parameters in assessing severe fibrosis in patients with chronic hepatitis B?

Authors : Mustafa Akar

Pages : 96-102

Doi:10.32322/jhsm.840794

View : 19 | Download : 11

Publication Date : 2021-01-21

Article Type : Research

Abstract :Background & Aims: This study was aimed to investigating the correlation between the severity of hepatic fibrosis and mean platelet volume (MPV) and comparing the accuracy rate of MPV with that of other long-used non-invasive parameters in predicting severe hepatic fibrosis in patients with chronic hepatitis B (CHB). Materials and Methods: Ninety-nine patients with CHB were enrolled. The patients were assigned to two groups, based on their hepatic fibrosis scores. Those with scores ranging from 0 to 3 (mild to moderate fibrosis) were assigned to Group 1, and those with scores ranging from 4 to 6 (severe fibrosis) were included in Group 2. Results: The mean age of the patients was 4213, and 69 (70%) of them were male. Twenty two patients (22%) were in Group 2. Patients in Group 2 displayed significantly lower albumin and platelet count (p<0.001), and significantly higher aspartate aminotransferase-to-platelet ratio index (APRI) and MPV (p<0.001). While the most sensitive (90%) test to show severe fibrosis was MPV at a cut-off value of ≥10 fl, the most specific (95%) test was platelet count at a cut-off value of ≤150x103/mm3. The accuracy rates of albumin, platelet count, MPV, and APRI were 79%, 91%, 90%, and 77%, respectively. Conclusions: Among the parameters for the detection of severe fibrosis in patients with CHB, the most sensitive test was MPV and the most specific test was platelet count. When assessed for their accuracy rates, it was determined that platelet count was superior to the other parameters.
Keywords : Albumin, aspartate aminotransferase to platelet ratio index, chronic hepatitis B, fibrosis, mean platelet volume, platelet count