Which Polymorphism Is The Distinguishing Factor For Fitness Athletes: The Ace Indel or Actn3 rs1815739?

Authors : Onur Eroğlu, Raif Zileli, Muhammed Ali Nalbant, Tolga Polat, Özlem Özge Yılmaz, Beste Tacal Aslan, Korkut Ulucan

Pages : 319-326

Doi:10.30621/jbachs.1264683

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Publication Date : 2024-05-31

Article Type : Research

Abstract :Purpose: The purpose of this research is to investigate the occurrence of ACE I/D and ACTN3 rs1815739 variations in sub-elite fitness athletes and to determine which gene is distinctive by comparing genotype and allele frequencies with sedentary individuals. Material and Methods: 41 sub-elite fitness athletes and 41 sedentary volunteers participated in the study. Genetic analyzes of the athletes were determined using molecular-based methods such as DNA isolation using a commercial kit, Real-time polymerase chain reaction (Real-Time PCR), and Polymerase chain reaction (PCR) after blood collection in EDTA tubes. The Chi-Square test was used to compare the genotype distribution and I, D, C, and T allele frequencies of ACE I/D and ACTN3 rs1815739 polymorphisms for statistical significance. Results: Analysis of data from our study revealed no statistically significant differences in ACE I/D polymorphisms between groups (p=0.4438), but statistically significant differences in ACTN3 rs1815739 polymorphisms significant difference (p=0.0313). Conclusion: In conclusion, in our study, it can be said that the ACTN3 gene is a distinguishing factor in fitness.
Keywords : ACE, ACTN3, fitness, gene, polymorphism, power