Exercise Capacity and Functional Status in Liver Transplant Candidates: Identifying perceived determinants and consequences

Authors : Tuba Ergene, Didem Karadibak, Şule Koç

Pages : 49-58

Doi:10.30621/jbachs.884024

View : 22 | Download : 9

Publication Date : 2021-05-27

Article Type : Research

Abstract :Purpose: Exercise capacity is an independent predictor of the disease prognosis in many clinical conditions. This study aims to predict the functional exercise capacity determinants and investigate the association between the functional status variables in liver transplant candidates. Methods: This prospective cross-sectional study consisted of thirty patients who were scheduled for liver transplantation. Respiratory and peripheral muscle strengths were measured using a mouth pressure device and a hand-held dynamometer, respectively. Dyspnea, physical activity, fatigue, exercise capacity, physical performance, and quality of life of participants were evaluated using the Modified Borg Scale, the International Physical Activity Questionnaire, the Turkish version of the Checklist Individual Strength Questionnaire, the Six-minute Walk Test, the 30-sec Sit-to-Stand Test, and the Liver Disease Symptom Index 2.0, respectively. A multivariate linear regression analysis was conducted to identify independent predictors of exercise capacity. Results: The six-minute walk distance was inversely and strongly correlated with dyspnea (r=−0.668, p<0.001) and age (r=−0.678, p<0.001) and had a strong positive correlation with Sit-to-Stand Test score (r=0.745, p<0.001). A moderate positive correlation was observed between six-minute walk distance and maximal inspiratory pressure (r=0.532, p=0.002), maximal expiratory pressure (r=0.522, p=0.003) and upper extremity muscle strength (r=0.479, p=0.007). Physical performance was a significant predictor of exercise capacity, accounting for 65.9% of the variance. Conclusion: Physical performance status may have a fundamental role in improving post-transplant outcomes in liver transplant candidates.
Keywords : Exercise Performance, Functional Level, Liver Failure