Analysis of the Long-Term Correlation Between Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A 10-Year Retrospective Study

Authors : Nur Aleyna Yetkin, Burcu Baran Ketencioğlu, Mohammed Almadqa, Fatma Sema Oymak, İnci Gülmez, Nuri Tutar

Pages : 52-56

Doi:10.55694/jamer.1457857

View : 24 | Download : 29

Publication Date : 2024-08-16

Article Type : Research

Abstract :Aim: The primary objective of this study is to evaluate the prevalence of overlap syndrome (OS) in patients with Chronic Obst- ructive Pulmonary Disease (COPD) who exhibit symptoms of Obstructive Sleep Apnea (OSA) and are undergoing polysomnog- raphy. The study also aims to explore the influence of hypoventilation and long-term oxygen therapy (LTOT) on the severity of OSA. Materials and Methods: A retrospective analysis was conducted on COPD patients presenting symptoms of OSA who underwent polysomnography between August 2012 and September 2022. Data on the patients’ body mass index (BMI), apnea-hypopnea index (AHI), oxygen desaturation index (ODI), minimum and mean oxygen saturation levels (minSpO2 and meanSpO2), sleep efficiency, percentage of REM period (REM%), LTOT usage, hematocrit levels, and awake arterial carbon dioxide (PaCO2) levels were collected. Results: The study involved 81 COPD patients. Among them, 76 individuals (93.9%) had an AHI>5, with 9 classified as having mild OSA, 24 as moderate OSA, and 43 as severe OSA. The average sleep efficiency was 78.3%, and the mean REM% value was 7.3. Sixteen patients (19.7%) were using LTOT, and a statistically significant higher sleep efficiency was observed in this group (p=0.048). Patients with elevated PaCO2 levels exhibited significantly higher AHI and ODI values compared to those with nor- mal PaCO2 levels (p=0.048, p=0.008, respectively). Additionally, the mean minSpO2 and meanSpO2 values were lower in the high PaCO2 group (p=0.013, p=0.008, respectively). Conclusion: In individuals with OS, reduced sleep efficiency is noted, and elevated PaCO2 levels are associated with decreased minSpO2 and meanSpO2 levels, higher ODI and AHI values. The utilization of LTOT is linked to improved sleep efficiency.
Keywords : apne, hipoventilasyon, obezite, polisomnografi