Evaluation of Plasma Lipid Levels in Intrahepatic Cholestasis of Pregnancy

Authors : Merve Öztürk Ağaoğlu, Zahid Ağaoğlu, Şevki Çelen

Pages : 190-194

Doi:10.52827/hititmedj.1321034

View : 28 | Download : 65

Publication Date : 2023-10-10

Article Type : Research

Abstract :Objective: To investigate the total cholesterol, triglyceride, LDL, VLDL, and HDL levels of pregnant women diagnosed with intrahepatic cholestasis of pregnancy and to examine the association with disease severity. Material and Method: A total of 80 pregnant women, 40 of whom were diagnosed with intrahepatic cholestasis of pregnancy, and 40 age-matched controls, were prospectively enrolled in this study. Lipid levels were compared among the case and controls, and their association with disease severity was analyzed. Birth weight, birth week, and neonatal outcomes were studied. Results: LDL and VLDL were significantly higher, and HDL levels were lower in the intrahepatic cholestasis of the pregnancy group than in the healthy pregnancies (p<0.05). Total cholesterol and triglyceride levels did not differ among the two groups. Birth weight, birth week, and 1-5-minute Apgar scores were lower, and the neonatal intensive care unit admission and the rate of primary cesarean section were higher in the group with intrahepatic cholestasis in pregnancy (p<0.05). In correlation analysis, a positive correlation was found between serum LDL and bile acids levels (r=0.349, p=0.027). LDL levels were significantly higher in severe disease than in mild disease (p=0.009) Conclusion: There are significant changes in lipid homeostasis in intrahepatic cholestasis of pregnancy. Abnormal lipid levels, such as high LDL and VLDL levels, could have a role in the pathogenesis, and in particular high LDL levels may contribute to the prediction of disease severity.
Keywords : Gebeliğin intrahepatik kolestazı, kolesterol, safra asitleri, triglseridler