Vitamin D deficiency and pregnancy outcome: Does it have a role in preeclampsia etiology?

Authors : Mehmet Tunc, Emre Günakan, Ceren Katar Yildirim, Nurten Çilek, Canan Tapkan, Onur Dalay

Pages : 80-84

Doi:10.52827/hititmedj.1127798

View : 30 | Download : 23

Publication Date : 2023-06-28

Article Type : Research Article

Abstract :Purpose: Vitamin D deficiency is higher in pregnancy and there is evidence on its relationship with various obstetric disorders. The aim of this study was to investigate the association between preeclampsia and vitamin D levels in pregnant women. Methods: This study included 1209 women. General characteristics, laboratory results and obstetric outcomes were evaluated. As globally accepted vitamin D deficiency was defined as <20 ng/mL and we determined a critical level of for deficiency that is 8.335 ng/mL in ROC analyses. Results: The median age of the patients was 28 (17-45). The percentage of need of labor induction was 11.9%. Cesarean section rate was 32.5%. The incidence of VDD was 81% (n:979). Gestational week (38.6 vs. 38.5), birth weight (3291gr vs. 3248gr) and head circumference (34.98cm vs. 34.9cm) were not different groups with regard to VDD (p: 0.145, p:0.184 and p:0.358, respectively). Besides; VDD was significantly associated with risk of labor induction and PROM in univariant analyses. 38 patients were diagnosed with preeclampsia. The diagnostic accuracy rate of level vitamin D level as 8.335 ng/mL was 76.1 %. According to multivariate analysis 25-OH vit D level of 8.335 ng/mL (HR: 2.94; 95%CI: 2.04-4.22; P < 0.001) and nulliparity (HR: 2.05; 95%CI: 1.43-2.93; P < 0.001) were independent factors significantly associated with preeclampsia. Conclusion: Low levels of vitamin D was associated with preeclampsia in our study. The association was stronger in lower levels. VDD is very frequent and further studies may also support advances in a health problem worldwide.
Keywords : 25-hidroksi vitamin D, , preeklempsi, gebelik, vitamin d eksikliği, sonuçlar