Cytotoxic Activity Studies of p-Chloro and Fluoro Substituted Formazan Derivatives on Lung and Prostate Cancer Cell Lines

Authors : Gülşen Türkoğlu, Senem Akkoç

Pages : 151-156

Doi:10.15671/hjbc.715102

View : 22 | Download : 10

Publication Date : 2022-02-28

Article Type : Research

Abstract :The cytotoxic activity properties of formazan derivatives (CF and FF) bearing halogen chlorine and fluorine groups placed at para position in 1-phenyl ring have been systematically investigated in this work. The synthesized two compounds were tested as anticancer agents against human cancerous cell lines for 48 h. The results obtained showed that these two compounds have cytotoxic effect towards screened cell lines. Particularly, compound FF having p-fluoro had more antiproliferative activity compared to CF in both studied cancer cell lines.
Keywords : Formazan derivatives, cytotoxic activity, prostate cancer, lung cancer