Malondialdehyde as an Indicator of Ischaemic Heart Disease

Authors : Afife Izbirak

Pages : 77-81

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Publication Date : 2007-04-01

Article Type : Other

Abstract :Lipids are the most involved class of molecules among the many targets of oxidative stress. Lipid oxidation producesa number of secondary products. The principal and most studied product of polyunsaturated fatty acid peroxidationis malondialdehyde MDA . Beside being a highly toxic molecule, malondialdehyde is also considered as a marker oflipid peroxidation. This study was intended to determine the lipid endoperoxide levels of some Turkish patients withischaemic heart disease findings at coroner angiography and verify whether malondialdehyde could be an indicatorof ischaemic heart disease. For this purpose lipid peroxide levels of the control and test groups were measured withspectrophotometric method which is based on the reaction between malondialdehyde and thiobarbituric acid. Statistical analysis of our results revealed a significant difference between the mean serum lipid peroxide levels of the patiens and the control group being 3.74±0.44 nmol/ml vs 2.72±0.53 nmol/ml respectively, and p=0.258. According tothese results we concluded that presence of MDA in serum at certain levels may predict the insurgence of vascularpathologies
Keywords : Oxidative stress, malondialdehyde, Lipid peroxidation, ischaemic heart disease