Disulfide-rich peptides in drug development

Authors : Şeyda Kara, Muharrem Akcan

Pages : 219-229

Doi:10.15671/hjbc.658764

View : 16 | Download : 16

Publication Date : 2020-06-15

Article Type : Review

Abstract :Peptides are important biomolecules in drug development with their high specificities to their targets. Many peptide-based drug candidates have been increasingly involved in clinical and preclinical studies. Unfortunately, peptides have some disadvantages such as poor metabolic stability, poor oral bioavailability and high production costs. These problems can be overcome by modifications that have been inspired from highly stable disulfide-rich peptides already found in nature. This review describes the structure and bioactivity of disulfide-rich peptides and their development with various modifications to become candidate molecules in drug design and development studies.
Keywords : Therapeutic peptides, drug development, cyclotides, peptide stability