Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

Authors : Arzu Birinci Yildirim, Esra Mutlu, Muhammet Yildirim

Pages : 237-246

View : 16 | Download : 9

Publication Date : 2018-06-03

Article Type : Research

Abstract :I n the present study, a series of thiazolo[3,2-c]pyrimidines (4,5) have been produced via simple and efficient synthetic method and their in vitro cytotoxicities have been performed on human breast (MCF-7) and hepatocellular (HEPG2/C3A) adenocarcinoma cell lines. The results of these in vitro tests revealed that at least five of thiazolo[3,2-c]pyrimidines exhibited strong cytotoxic effects at very low concentrations, which were very similar or lower than that of reference anticancer agent, 5-FU, against MCF-7 and HEPG2/C3A cancer cell lines.
Keywords : Anticancer, breast cancer, Mannich cyclisation, thiazolopyrimidines