Synthesis, Characterization and the Photodynamic Activity against Some Gram negative and positive Bacteria of Novel Subphthalocyanine Derivative

Authors : Bircan Dindar, Mine Ince, Özlem Seven

Pages : 1-10

View : 16 | Download : 7

Publication Date : 2013-03-31

Article Type : Other

Abstract :A specific tris (3,5-di- tert -butyl-4-hydroxyphenyl) Subphthalocyanine hydroxyde ( SubPc-1) derivative was synthesized and the structure of SubPc-1 was confirmed by UV-Vis, Fluorescence, FTIR, 1 H NMR, 13 C NMR and MALDI-TOF-MS spectroscopy. Its thermal stability and photostability tests were checked by using TGA and solar simulator, respectively. In addition, the singlet oxygen produced capacity of amphiphilic SubPc-1 was determined for PDT studies. Besides, the p hotodynamic activity of this novel product against some of gram negative bacteria ( Escherichia coli, Pseudomonas aeruginosa ) and gram positive bacteria ( Staphylococus aureus, Enterococcus faecalis ) has been investigated by using a xenon lamp which emits light in the ultraviolet-visible region and is simulated for solar light as the illumination source . It was determined that the peripheral hydrophilic groups provided great opportunities in inactivation and solubility studies. This new amphiphilic macromolecule was especially found as an effective photosensitizer against gram positive bacteria in PDT, in particular .
Keywords : Subphthalocyanine, photosensitizer, biological activity, bacteria, photodynamic inactivation,