Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation

Authors : Volkan Yanmaz, Ali Disli, Serkan Yavuz, Hatice Ogutcu, Gulay Dilek

Pages : 78-89

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Publication Date : 2019-03-01

Article Type : Research

Abstract :A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reaction. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermis , M. luteus , B. cereus , B. abortus and C. albicans when compared to standard drugs. 
Keywords : Isoxazolidine, Nitrone, 1-3 Dipolar cycloaddition reaction, Antimicrobial activity