IN VITRO BIOLOGICAL ACTIVITY STUDIES ON TANACETUM ABROTANIFOLIUM (L.) DRUCE (ASTERACEAE)

Authors : Ibrahim Geçibesler

Pages : 439-455

Doi:10.18038/aubtda.284496

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Publication Date : 2017-06-30

Article Type : Research

Abstract :Tanacetum L. (Asteraceae) species have been used by local people in folk medicine for centuries in Turkey to treat antipyretic, headache, tinnitus, dizziness and against difficulties in childbirth. We performed detailed biological activity screening tests of Tanacetum abrotanifolium , collected from its natural habitats in the eastern region of Turkey, for the first time. To obtain active compound from aerial parts of T. abrotanifolium by using chromatographic techniques, anticancer, antimicrobial and antioxidant assays were applied. Total phenol, flavonoid, β -carotene and lycopene contents were determined quantitatively. The isolation procedure was carried out successfully through thin layer and column chromatographies. Bioactivity-guided fractionation led to the isolation of luteolin-7- O -glucoside, an agent of anticancer, antimicrobial and antioxidant. This active compound was isolated from aerial parts of T. abrotanifolium for the first time.
Keywords : Tanacetum abrotanifolium, luteolin-7-O-glucoside, anticancer activity, antimicrobial potency