OPTIMIZATION AND EVALUATION OF MOISTURIZING CREAM CONTAINING DEXPANTHENOL

Authors : Arkan Yashar Barbar, Mohammed Kakayi, Buket Aksu

Pages : 9-20

View : 14 | Download : 5

Publication Date : 2023-04-30

Article Type : Research Article

Abstract :Background/aim: The main purpose of this work was to prepare and evaluate a moisturizing cream containing dexpanthenol. Materials and methods: In this study, several cream formulations were prepared using the oil-in-water (O/W) emulsion technique to investigate the effect of varying concentrations of the independent variable on the physical appearance, pH, electrical conductivity, viscosity and spreadability. Different formulations were prepared with different combinations of Cera alba and Stearic acid with various excipients. The developed formulations were examined with the QbD approach. A process known as \"quality by design\" uses statistical, analytical, and risk-management techniques in the planning, development, and production of pharmaceuticals to guarantee the predetermined quality of the product. Results: According to the QbD studies, the Design Space is given for optimum formulae. After establishing the model equations for the main effects and responses, various cream formulations containing stearic acid and cera alba were optimized based on spreadability, viscosity, and electrical conductivity. Conclusion: In conclusion, the outcomes of different formulations obtained in this research study clearly showed that a moisturizing cream containing a certain ratio of Cera alba and Stearic acid have an up-and-coming potential. Therefore, proportions of Cera alba and Stearic acid are included in the moisturizing cream to win its cosmetic benefits.
Keywords : QbD, dekspantenol, sürülebilirlik, dokusal