Impact of Erythrocyte Transfusion on Thiol/Disulfide Homeostasis in Anemic Patients

Authors : Selçuk Coşkun, Ferhat İçme, Yücel Yüzbaşıoğlu, Fatih Tanrıverdi, Gül Pamukçu Günaydın, Cagri Serdar Elgormus, Özcan Erel, Salim Neşelioğlu

Pages : 63-66

Doi:10.54996/anatolianjem.1468418

View : 54 | Download : 56

Publication Date : 2024-06-29

Article Type : Research

Abstract :Aim: Anemia limits oxygen delivery to tissues, potentially leading to increased oxidative stress. This study examined the impact of erythrocyte transfusion on thiol/disulfide homeostasis, a marker of oxidative stress, in anemic patients. Material and Methods: Sixty anemic patients receiving transfusions in emergency department were included in this study. We measured total thiol, native thiol, and disulfide levels in blood samples collected before and after red blood cell transfusion. To isolate the effects of anemia, a subgroup analysis that excluded patients with acute/subacute hemorrhage or aplastic anemia was also done. Results: The concentrations of total thiol (374.24±94.84 to 344.6±88.5) and native thiol (338.91±90.51 to 304.91±90.95) significantly decreased after erythrocyte suspension treatment compared to baseline (P<0.0001). However, the disulfide level increased (17.75±6.63 to 20.97±7.25; p = 0.009). Our findings suggest a potential increase in overall oxidative stress. Conclusion: By giving transfusions to anemic patients one may think that oxidative stress will be reduced due to increased oxygen carrying capacity but our results show the contrary. Our results support that oxidative stress increases in vivo in patients who receive transfusion right after the procedure and this is probably due to increased oxidative stressin stored erythrocyte suspensions.
Keywords : Anemi, disulfide, eritrosit transfüzyonu, sulfhidrid bileşikleri, oksidatif stres