Sağlıklı ve Koksidiyozlu Etlik Piliçlerde Sülfakinoksalin’in Farmakokinetiği

Authors : Fatma Şahindokuyucu Kocasari, Ali Bilgili

Pages : 7-14

Doi:10.30782/uluvfd.383350

View : 31 | Download : 10

Publication Date : 2014-12-12

Article Type : Research

Abstract :p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Times New Roman'; min-height: 15.0px} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px 'Times New Roman'} span.s1 {font: 12.0px 'Times New Roman'} span.s2 {font: 6.5px 'Times New Roman'}   The aim of this study is to investigate the pharmacokinetics parameters of sulphaquinoxaline after single administration of 100 mg/kg b.w. to healty and Eimeria tenella (E. tenella) infected chickens. In this study, 35 one-day-old, male Avian race, broiler chicks were used. The animals were divided into 5 equal groups (Grup I, II, III, IV and V) and consisting of 7 chicks in each. The animals in Group IV and V were infected on 24 th days with E. tenella inoculum that contains 10 000 E. tenella oocysts. The medicine was applied to all chickens on 30 th days. The drug was given intravenously to Group I, intracrop to Group II and Group IV, in drinking water to Group III and Group V. After the drug administration; 0,08., 0,25., 0,50., 1., 1.5., 2., 4., 6., 8., 12., 18., 24., 30, and 36 th hours, blood were taken from animals to heparinised tubes. The drug concentration levels in plasma samples were determined by spectrophotometry. The plasma concentration-time curve, deter-mined after the administration of sulphaquinoxaline intravenous, showed that the drug distributed according to two-compartment open model. When the drug given to coccidiosed animals intracrop, compared to healthy ani-   mals, there were significant increases (p<0.05) in absorbtion rate constant (k a ) and hybrid rate constants repre-senting the slopes of distribution phase (α); and there were significant decreases (p<0.05) in hybrid rate con-stants representing terminal phase half life (t 1/2α ), hybrid rate constants representing terminal phase half life (t 1/2β ), absorption half-life (t 1/2a ), average retention time of drug (MRT), drug elimination rate constant (k 10 ) and plasma to maximum level (t max ). When given via drinking water to coccidiosed animals compared to healthy animals, there were statistically significant increases (p<0.05) in k a and α; and significant (p<0,05) decrease in t 1/2α , t 1/2β , t 1/2a , distribution volume of central compartment (V 1 ) an MRT. Finally, according to data came from healthy and coccidiosed chicken, if the medicine would be used at the dose of 100 mg /kg c.a. via drinking wa-ter, it should be repeated 18 hour intervals for the benefit of highest efficacy of medicine. In coccidiosis cases, there is no need for the different administration route, because of insignificancy regarding administration intervals.   p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px 'Times New Roman'} span.s1 {font: 6.5px 'Times New Roman'}
Keywords : Etlik Piliç, farmakokinetik, koksidiyoz, sülfakinoksalin