A review of the role of platelet rich fibrin in healing and regenerative process and its use in orthopaedic surgery

Authors : Turan Cihan Dülgeroğlu, Baran Şen

Pages : 354-361

Doi:10.17343/sdutfd.451366

View : 18 | Download : 10

Publication Date : 2019-09-01

Article Type : Review

Abstract :Platelet-rich fibrin (PRF) is a naturally derived fibrin scaffold and second-generation platelet concentrate with great potential for promoting wound healing and the regenerative process via the secretion of different cytokines and growth factors, enhanced osteoblast adhesion, and augmentation of collagen protein expression. Given the significance of the scope of PRF in the field of orthopedic surgery, this study presents an overview for the role of PRF in the recovery and the regenerative process with emphasis on its rationale for use and outcome in orthopedic surgery. In conclusion, PRF offers a new dimension for clinical research with expanded range of potential applications in orthopedic surgery with a simpler preparation protocol, a stronger and more stable fibrin polymerization leading to a physiologic architecture, occurrence of natural clot formation allowing formation of a flexible and fine fibrin network and a continual and steady release of cytokines and growth factors, mimicking the requirements of the reparative tissue and wound healing processes. 
Keywords : Platelet rich fibrin, wound healing, tissue regeneration, growth factors, orthopedic surgery