Administration of Anticonvulsant Drugs by the Intraperitoneal Route

Authors : Ruşen Dündaröz, Tuncer Değim, Ali Sizlan, Mehmet Yaşar, Metin Denli, Uğur Tamer

Pages : 0-0

Doi:10.17343/sdutfd.27079

View : 29 | Download : 11

Publication Date : 2009-03-12

Article Type : Research

Abstract :SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 1999 Eylül; 6(3) Administration ofAnticonvulsant Drugs by the Intraperitoneal Route Ruşen Dündaröz, Tuncer Değim, Ali Sızlan, Mehmet Yaşar, Metin Denli, Uğur Tamer Abstract Status epilepticus or seizures cause serious brain damages and irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs can be introduced to the patients intravenously (IV), hut it is almost impossible to achieve IV access during the seizure. Intraperitoneal (IP) route can be accessible but, IP route of administration of antiepileptic drugs has not been used so far. Therefore the possibility of IP administration of anti epileptic drugs was investigated in this study. Antiepileptic drug (diazepam, phenytoin or phenobarbital) was introduced rabbits and dogs by IV and IP routes and blood samples were collected by the time during the period of 60 to 120 minutes. Blood samples vere analyzed and drug contents -were determined. The plasma profiles of antiepileptic drugs were obtained and compared. The plasma profiles of antiepileptic drugs were found to be low when they were administered by IP route. It was concluded that the IP administration of antiepileptic drugs could not be an alternative route to IV administration. Key Words: Convulsion, anticonvulsant drugs, Intraperitoneal route Antikonvülzon İlaçların İntraperitonal Yoldan Verilmeleri Özet Epilepsi veya epilepsi nöbeti ciddi beyin hasarlarına neden olabilir, ve eğer fazla uzun sürerse geri dönüşsüz beyin harabiyetine neden olabilir, bu nedenle nöbetin süratle durdurulması oldukça önemlidir. Antiepileptik ilaçlar hastalara intravenöz(IV) yolla verilebilir ancak nöbetler esnasında hastaya IV ulaşım hemen hemen imkansızdır ancak intraperitonal(IP)yol ile ilaç verilmesi mümkündür.
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