Clinical and laboratory factors affecting chronicity in children diagnosed with immune thrombocytopenia

Authors : Yılmaz Ay, Hakan Sarbay

Pages : 535-540

Doi:10.31362/patd.695982

View : 20 | Download : 5

Publication Date : 2020-09-18

Article Type : Research

Abstract :Purpose: Immune thrombocytopenia (ITP) is one of the most common hematologic disorders in childhood. Approximately 20-25% of patients with newly diagnosed ITP become chronic. We aimed to investigate the risk factors that may affect chronicity of ITP. Materials and Methods: A total of 75 pediatric patients with ITP who were admitted to the Pediatric Hematology Department of Pamukkale University Faculty of Medicine Hospital between January 2013 and July 2018 were included in the study. The patients’ characteristics such as clinical features, laboratory results, treatment requirements and type of treatment were retrospectively evaluated using the hospital's information system. Results: 46 (79,3%) of the 58 patients with ITP were acute and 12 (20,7%) of those were chronic. The mean age of the patients with acute ITP were 4 ± 3,84 years, while the mean age of the patient with chronic ITP were 9,6 ± 4,6 years. Statistical analysis revealed that children with a diagnosis age greater than 10 years had a significantly higher rate of chronicity. The dominant season in acute cases was spring with 34,8%, while in chronic cases it was summer with 50%. Acute cases were significantly higher in the spring season. 26 of 46 patients with acute ITP (56,5%) and 3 of 12 patients with chronic ITP (25%) were treated with IVIG firstly. Conclusion: We determined that in newly diagnosed patients with ITP who are older 10 years of age and no history of infection may have high risk of chronicity, while the patients diagnosed in the spring and administered IVIG may have less chronicity.
Keywords : Immune thrombocytopenia, pediatric, chronic