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- Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptid...
Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model
Authors : Şeyma Nur BAŞARIR BOZKURT, Oguz MUTLU, Daniel BERMEJO RODRİGUEZ, David KACER, Pelin TANYERİ, Pınar COBANTÜRK, Karel VALES
Pages : 525-532
Doi:10.26453/otjhs.1374368
View : 29 | Download : 53
Publication Date : 2023-12-18
Article Type : Research
Abstract :Objective: Adipokinetic hormone (AKH) plays a role in sugar and lipid metabolism in insects. Previous studies of AKH showed memory improvements in a schizophrenia rat model that displayed memory impairment and reduced depression in a rat olfactory bulbectomy model. In this study, we investigated the effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on brain neurotransmitter levels and brain neurochemistry in a schizophrenia rat model. Materials and Methods: We administered AKH/RPCH peptides for 4 days sub-chronically, both in naive rats and also in the MK-801-induced schizophrenia rat model. Liquid chromatography-mass spectrometry apparatus was used for targeted and untargeted analysis of rat neurochemistry. Results: Increased brain glutamate levels characteristic of MK-801 peptide-treated rats were significantly reduced by AKH. Furthermore, AKH also increased brain dopamine levels in both naive and MK-801 rats. Metabolomic studies have shown that AKH affects lipid and glutamate metabolism, while hypertrehalosaemic hormone plays a role in sugar metabolism and inflammation. Conclusion: According to our results, AKH might affect dopaminergic and glutamatergic systems and reverse the effects of MK-801, possibly affecting NMDA receptors.Keywords : Adipokinetik hormon, nörokimya, nörotransmitter, şizofreni