- Online Türk Sağlık Bilimleri Dergisi
- Vol: 8 Issue: 3
- Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease
Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease
Authors : Mahmud Islam, Hamad Dheir, Elif Özözen Şahin, Selcuk Yaylaci, Abdülkadir Aydin, Musa Pinar, Ertuğrul Güçlü, Ahmed Cihad Genç, Mehmet Köroğlu, Oğuz Karabay
Pages : 363-368
Doi:10.26453/otjhs.1276809
View : 28 | Download : 40
Publication Date : 2023-09-06
Article Type : Research Article
Abstract :Objective: Interferon-gamma inducible protein-10 (IP-10) released from macrophages is associated with thrombosis. We aimed to investigate patients\' biochemical markers following severe COVID-19, concentrating on the role of IP-10 in mortality. Materials and Methods: In our study, we retrospectively evaluated data from 88 (females, 44.3%) severe patients followed in our university hospital\'s intensive care unit (ICU). We obtained demographic and laboratory data from our study population\'s files and electronic records, including D-dimer, ferritin, uric acid, IP-10 values, and other biochemical markers. Results: The mean age of all 88 patients with COVID-19 infection followed in the ICU was 70.5 ±10 years. The median for lymphocyte count was 1.3 (1-2.1) vs 0.8 (0.5-1.1) K/uL, ferritin 151 (90.7-255) vs 624 (296-1254) mcg/L, D-dimer 386 (293.5-650) vs 1280 (871-2245) ug/L, LDH 220 (185-286) vs 429.5 (368-560) U/L with a p-value of <0.05 in survivors vs non-survivors respectively. On the other hand, the level of IP-10 was 21.3 (13.2-31.6) vs 26.6 (11.4-43.6) pg/mL with a p-value of 0.04. Conclusions: In this study, in which non-survivors and survivors were compared in severe COVID-19 patients, it was found that ferritin and D-dimer were good predictors of mortality, while IP-10 could not be a predictor of mortality.Keywords : Biyobelirteç, COVID-19, IP-10, mortalite