- Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
- Vol: 10 Issue: 2
- Association between serum netrin-1 level and obesity-related markers in obese subjects
Association between serum netrin-1 level and obesity-related markers in obese subjects
Authors : Çiğdem Aydin Acar, Niyazi Aydin, Suray Pehlivanoğlu, Mehmet Kök
Pages : 108-115
Doi:10.24998/maeusabed.1130028
View : 11 | Download : 7
Publication Date : 2022-08-26
Article Type : Research
Abstract :Netrins are important signaling proteins that guide both neural and vascular development. Netrin-1 regulates many physiological processes such as cell proliferation, adhesion and migration. The aim of this study was to determine the association between serum netrin-1 level and biochemical parameters in obese subjects. Serum samples were collected from obese (n=15) and control (n=30) subjects. The serum netrin-1 levels were evaluated by ELISA. Variable data were compared by Mann Whitney U test and correlation was estimated by Spearman correlation analyses. The level of circulating netrin-1 protein was determined to be significantly lower in obese group compared to controls. The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group (p<0.0001). Serum netrin-1 level was negatively correlated with HbA1c, LDL, cholesterol and triglyceride (P< 0.01). In addition, ROC curve analysis indicated that netrin-1 level could define the presence of obesity with AUC value of 0.8667 (95% Cl=0.7249-1.000; P<0.0001). Our study suggests that netrin-1 secretions are significantly reduced in obese subjects and negatively correlated with obesity markers. Therefore, netrin-1 can be evaluated as a possible potential biomarker for obesity.Keywords : Obezite, Netrin-1, ELISA, Biyobelirteç