- Maltepe Tıp Dergisi
- Vol: 15 Issue: 1
- Evaluation Of The Frequency Of Vitamin D Deficiency And Its Relationship With Disease Involvement In...
Evaluation Of The Frequency Of Vitamin D Deficiency And Its Relationship With Disease Involvement In Patients With Systemic Sclerosis
Authors : Kezban Armagan, Özgül Soysal Gündüz
Pages : 10-16
Doi:10.35514/mtd.2023.82
View : 11 | Download : 7
Publication Date : 2023-04-30
Article Type : Research
Abstract :Objective: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by vasculopathy, visceral and cutaneous fibrosis. Vitamin D has various functions in the immunological system and different studies have shown a potential role in triggering autoimmune diseases. Patients with SSc may present with low serum vitamin D levels, but the relationship between low vitamin D levels and disease and clinical manifestations is still unclear. Our aim is to determine the frequency of vitamin D deficiency in patients with scleroderma and to analyze the relationship between vitamin D concentration and organ involvement of systemic sclerosis. Material and Methods: This study retrospectively scanned the files of 54 patients with systemic sclerosis and compared them with the control group. Serum levels of 25-hydroxyvitamin D were measured and the two groups and Systemic sclerosis subgroups were compared. Systemic sclerosis subgroups were also analyzed for organ involvement. Results: Fifty-four SSc patients ( 49 females, mean age 53.25 ± 10.77 years, and the median disease duration 8 (1-25) years) and 50 controls (45 females, mean age 51.02 ± 9.14 years) were included. In the Systemic sclerosis group, 7 patients (12.9%) had severe vitamin D deficiency (<5 ng/ml) and 46 patients (85.1%) had vitamin D deficiency (20 - 5 ng/ml), while optimal vitamin D level was not found. There was a significant decrease in vitamin D in the patient group compared to the healthy control (p=0.001). There was no significant difference in the analysis of Systemic sclerosis subgroups except for pulmonary involvement (p=0.019) and DLCO (p=0.023).The correlation between 25-hydroxyvitamin D concentration and age, acute phase reactants, autoantibody profile, degree of skin involvement, disease activity and respiratory tests and vitamin D was not found. Conclusion: Serum vitamin D concentrations of patients with SSc were significantly lower than healthy controls. There was no significant correlation between skin involvement, disease activity and 25-hydroxyvitamin D level.Keywords : Sistemik skleroz, 25-hidroksivitamin D, cilt tutulumu, pulmoner tutulum