- KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi
- Vol: 4 Issue: 1
- A case report of Glanzman Thrombasthenia with anterior mediastinal hematoma and Factor V Leiden muta...
A case report of Glanzman Thrombasthenia with anterior mediastinal hematoma and Factor V Leiden mutation
Authors : Hüseyin Tokgöz, Ümran Çalişkan, Tuğçe Duran, Kaniye Zeynep Çalişkan Sak
Pages : 17-22
Doi:10.59244/ktokusbd.1173506
View : 37 | Download : 57
Publication Date : 2023-04-28
Article Type : Research Article
Abstract :Glanzmann thrombasthenia (GT) is an autosomal recessive disease associated with platelet aggregation dysfunction with normal platelet count, causing bleeding diathesis. GT is characterized by decreased levels or decreased function of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex and therefore results in an increased tendency to bleeding as the aggregation phase of primary hemostasis cannot be sufficiently formed. Factor V Leiden mutation is a genetic mutation predisposing to thrombophilia. We present this case in which Factor V and Glanzmann thrombasthenia with hematoma in the anterior mediastinum are rarely seen together.Keywords : Factor V Leiden, Glanzmann trombasteni, Hematom, Trombofili