- Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi
- Cilt: 20 Sayı: 4
- Comparison of placental pathologies in pregnant women with COVID-19 according to disease severity
Comparison of placental pathologies in pregnant women with COVID-19 according to disease severity
Authors : Nihat FARİSOĞULLARI, Bedri SAKCAK, Atakan TANACAN, Özgür KARA, Ezgi BAŞARAN, Ramazan DENİZLİ, Kamil Hakan MÜFTÜOĞLU, Dilek SAHİN
Pages : 1975-1981
Doi:10.38136/jgon.1263841
View : 17 | Download : 38
Publication Date : 2023-12-31
Article Type : Other
Abstract :Aims: To evaluate the placental pathologies of pregnant women diagnosed with COVID-19 according to disease severity. Materials and method: This retrospective study was conducted at a tertiary center between April 2020 and February 2023. The placentas of 125 pregnant women in their third trimester who were positive for SARS-CoV-2 were examined. Placental pathologies were classified according to the modified Amsterdam criteria. According to the disease severity, the patients were divided into two groups: non-severe COVID-19 (n=104) and severe COVID-19 (n=21). Placental pathology results were compared between the two groups. Results: The rates of maternal vascular malperfusion (MVM) and fetal vascular malperfusion (FVM) were 90.4% and 45.2% in the non-severe COVID-19 group. Whereas it was significantly lower at 71.4% and 19% in the severe COVID-19 group (p=0.018 and p=0.026, respectively). The rate of delayed villous maturation (DVM) was 9.5% in the severe COVID-19 group and 1% in the non-severe COVID-19 group, indicating a statistically significant difference (p=0.019). Inflammatory pathologies and other pathological findings were similar between the two groups. Intensive care unit (ICU) admission, presence of accompanying maternal diseases, and postpartum complications were statistically significantly higher in the severe COVID-19 group (p<0.05). Conclusion: Whereas MVM and FVM lesions were observed at a higher rate in patients with non-severe COVID-19, DVM lesions and normal placentas were more common in those with severe COVID-19. The presence of different placental pathologies in SARS-CoV-2 patients according to the severity of the disease may be associated with the acute or chronic course of the disease.Keywords : plasental patoloji, SARS-CoV-2, retroplasental hematom