- Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi
- Cilt: 20 Sayı: 3
- Evaluation of the myeloperoxidase/paraoxonase1 ratio as the determinant of dysfunctional HDL in poly...
Evaluation of the myeloperoxidase/paraoxonase1 ratio as the determinant of dysfunctional HDL in polycystic ovary syndrome
Authors : Esin Merve EROL KOÇ, Selen YAMAN, Meryem CEYHAN, Salim NESELİOGLU, Özcan EREL, Melike DOĞANAY
Pages : 1804-1809
Doi:10.38136/jgon.1313215
View : 24 | Download : 30
Publication Date : 2023-10-01
Article Type : Research
Abstract :Aim: The myeloperoxidase/paraoxonase1(MPO/PON1) ratio is known to reflect the dysfunctional HDL(d-HDL) which is a measure of oxidative stress. This study aimed to evaluate the MPO/PON1 ratio in polycystic ovary syndrome(PCOS). Materials and Method: This prospective study included a total of 123 patients. The study group including the women with the diagnosis of PCOS (n=63) was compared to the control group including the healthy women (n=60). Sociodemographic characteristics, and clinical features of the groups were recorded. Serum HDL level, MPO, and PON1 activities were evaluated. Results: The PCOS patients were observed to have increased MPO and decreased PON1 activities (p<0.0001 and p=0.007, respectively). The d-HDL and was found to be significantly higher in PCOS patients compared to the healthy controls (0.56 (0.24) vs. 0.50 (0.12), p<0.0001). There were also significant associations between the oxidative parameters and PCOS related findings (p<0.05). Conclusion: Besides the increased MPO/PON1 ratio which defined as d-HDL, the increased MPO and decreased PON1 activities also supported the increased oxidative status in PCOS patients. Our results may be considered to draw attention to oxidative stress and dyslipidemia in PCOS patients, even in the early periods of the women life.Keywords : Disfonksiyonel HDL, MPO/PON1, Oksidatif stres, PCOS