- İstanbul Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 32
- ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM
ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM
Authors : S. Aydin O. Özdemir
Pages : 43-50
View : 20 | Download : 30
Publication Date : 2015-09-09
Article Type : Research
Abstract :Arnitriptyline, a tricyclic antidepressant which is mainly used for major depression treatment, was investigated about its antimuscarinic effects and as a result it was found generally non-selective and 100 fold less active than atropine (1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic activity and selectivity. Experiments were based on measuring agonist and antagonist responses in isolated tissues in physiological conditions. Key words: Antimuscarinic activity, Tricyclic antidepressants, Arnitriptyline, Opipramole.Keywords : Antimuscarinic activity, Tricyclic antidepressant, Arnitriptyline, Opipramole