- İstanbul Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 46 Issue: 1
- Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery appl...
Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications
Authors : Imren Esentürk, M. Sedef Erdal, Sevgi Güngör
Pages : 49-69
View : 22 | Download : 11
Publication Date : 2016-08-24
Article Type : Review
Abstract :Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.Keywords : Nanofiber, electrospinning, topical drug delivery, transdermal drug delivery