- İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi
- Cilt: 22 Sayı: 44
- SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES
SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES
Authors : Şule Erol Günal
Pages : 417-424
Doi:10.55071/ticaretfbd.1364818
View : 58 | Download : 70
Publication Date : 2023-12-31
Article Type : Research
Abstract :Fluorine-containing compounds play a significant role in drug development because fluorine atom has unique chemical properties due to its high electronegativity which significantly influences the properties important for drug design. In the present study, 2-fluorobenzoyl thiourea derivatives were synthesized by the reaction of 2-fluorobenzoyl isothiocyanate, which was obtained by the reaction of 2-fluorobenzoyl chloride with ammonium thiocyanate, with appropriate aniline derivatives. The structures of the benzoyl thioureas were confirmed by IR, 1H and 13C NMR spectroscopy.Keywords : Tiyoüreler, Benzoil tiyoüreler, florlu bileşikler