- İstanbul Tıp Fakültesi Dergisi
- Vol: 86 Issue: 2
- THE DIAGNOSTIC ROLE OF 18F-FDG-PET/CT IN PATIENTS WITH CONSTITUTIONAL SYMPTOMS
THE DIAGNOSTIC ROLE OF 18F-FDG-PET/CT IN PATIENTS WITH CONSTITUTIONAL SYMPTOMS
Authors : Mustafa Altinkaynak, Nevzat Kahveci, Yağmur Göksoy Solak, Emine Göknur Işik, Sebile Nilgün Erten, Bülent Saka, Timur Akpinar
Pages : 145-151
Doi:10.26650/IUITFD.1183149
View : 31 | Download : 34
Publication Date : 2023-03-30
Article Type : Research Article
Abstract :Objective: The contribution of 18F-FDG-PET/CT to diagnosis and its role in differential diagnosis were investigated in patients examined for constitutional symptoms. Materials and Methods: The 18F-FDG-PET/CT scan results and clinical data were analyzed retrospectively in 144 patients with constitutional symptoms examined between January 2017 and December 2019 in our outpatient and inpatient clinics in Istanbul University Istanbul Faculty of Medicine Internal Medicine Department. The FDG uptake other than physiological FDG uptake was considered as PET-positive. Clinical, laboratory data, and 18F-FDGPET/ CT scan results were evaluated retrospectively from records. All patients were classified into four categories as malignancies, infectious diseases, rheumatic diseases and other diseases based on their definitive diagnoses. The contribution of 18F-FDG-PET/CT in establishing a definitive diagnosis was investigated. Results: The 144 patients comprised 85 (59.0%) men and 59 (41.0%) women with a mean age of 58.0±17.2 years. The mean duration of symptoms was 4.01±4.46 months. A definitive diagnosis was established in 95.1% (n=137) of the patients based on physical examination, imaging methods, laboratory tests, and other diagnostic tests. In comparison, no definitive diagnosis was established in the remaining 4.9% (n=7) of the patients. 18F-FDGPET/ CT contributed to diagnosis in 86.8% (n=119) of patients. The patients were classified into four categories based on their diagnoses: (i) malignancies (n=79; 57.7%), (ii) rheumatic diseases (n=22; 16.1%), (iii) infectious diseases (n=19; 13.9%), and (iv) other diseases (n=17; 12.4%). The sensitivity, specificity, and positive and negative predictive values of 18F-FDG-PET/CT in the diagnosis of constitutional symptoms were 97.5%, 31.8%, 88.8%, and 70%, respectively. Conclusion: We found that 18F-FDG-PET/CT is a valuable diagnostic tool in diagnosing patients with constitutional symptoms and provides high sensitivity and positive predictive value.Keywords : 18F-FDG-PET/BT, konstitüsyonel semptomlar, tanı, malignite