- Harran Üniversitesi Tıp Fakültesi Dergisi
- Cilt: 20 Sayı: 3
- Exploring the Potentials of Flavonoids on Brain Function: Effects of Three Phenolic Compounds on Bra...
Exploring the Potentials of Flavonoids on Brain Function: Effects of Three Phenolic Compounds on Brain Electrical Activity
Authors : Hilal Öztürk, Harun Başoğlu, Selcen Abidin, Ismail Abidin
Pages : 525-532
Doi:10.35440/hutfd.1328652
View : 39 | Download : 91
Publication Date : 2023-12-31
Article Type : Research
Abstract :Background: The most common polyphenolic compounds taken up by the organism through the food chain are flavonoids. Known to cross the blood-brain barrier, 7,8-DHF, L-theanine and Fisetin are re-ported to have neuronal effects as well as therapeutic potential for neurodegenerative diseases. How-ever, little is known on their acute effects of neuronal function. This study aims to describe the effects of the mentioned flavonoids on the total ECoG activities and band analyzes of healthy mice. Materials and Methods: For this purpose, 3 different groups consisting of 7 subjects were created for each flavonoid administration. After the baseline electrophysiological recordings, flavonoid administra-tion was performed and acute effects were determined. Results: 7.8-DHF increased the theta, alpha and beta band activities while decreasing the total ECoG power. L-theanine and Fisetin did not significantly alter the total ECoG activity. However, L-theanine statistically increased theta, alpha and beta band activities. Conclusions: In conclusion, our data showed that flavonoids could acutely modulate the ECoG respons-es in a band specific manner. They can be considered as candidate molecules for drug discovery studies for central nervous system disorders.Keywords : Flavanoidler, Elektrokortikografi, Bant aktiviteleri