- Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 43 Issue: 1
- Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR
Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR
Authors : Alankar Shrivastava, Ashu Mittal
Pages : 22-31
Doi:10.52794/hujpharm.1092728
View : 7 | Download : 2
Publication Date : 2023-03-01
Article Type : Research
Abstract :The Benign Prostatic Hyperplasia is one of the common old age problems and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was undertaken to establish the compatibility of Tamsulosin with several commonly used excipients by using thermo analytical technique viz Thermogravimetry and differential scanning calorimetry used in formulation. The Thermogravimetry and differential scanning calorimetry both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.Keywords : Tamsulosin, Differential scanning calorimetry, Thermogravimetry, Incompatibility study, Fourier transform Infra Red