- Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 42 Issue: 3
- Prospects for the search for new biologically active compounds among the derivatives of the heterocy...
Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole
Authors : Yurii Sameliuk, Andrii Kaplaushenko, Natalia Nedorezaniuk, Liusine Ostretsova, Feodosiia Diakova, Bogdan Gutyj
Pages : 175-186
Doi:10.52794/hujpharm.1019625
View : 18 | Download : 8
Publication Date : 2022-09-01
Article Type : Review
Abstract :The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Sys- tematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.Keywords : Biological activity, bibliosemantic method, organic synthesis, 1, 2, 4-triazole