- Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 42 Issue: 3
- N’-(2-(5-((Theophylline-7-yl)methyl)- 4-ethyl-1,2,4-triazole-3-ylthio)acetyl) isonicotinohydrazide A...
N’-(2-(5-((Theophylline-7-yl)methyl)- 4-ethyl-1,2,4-triazole-3-ylthio)acetyl) isonicotinohydrazide As Antitubercular Agents
Authors : Andrey Gotsulya, Vladimir Zazharskyi, Volodymyr Parchenko, Pavel Davydenko, Oleg Kulishenko, Tetyana Brytanova
Pages : 149-155
Doi:10.52794/hujpharm.1011368
View : 14 | Download : 6
Publication Date : 2022-09-01
Article Type : Research
Abstract :The paper presents the results of histological studies of tuberculosis in rabbits in an experimental model with comparative treatment with isoniazid and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. The calculated dose of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotino-hydrazide for subcutaneous administration indicates its prospects for veterinary practice as an effective and safe tuberculocidal drug.Keywords : tuberculosis, experimental model, rabbits, 1, 2, 4-triazole