- Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi
- Vol: 42 Issue: 2
- Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety
Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety
Authors : Roman Shcherbyna, Yevhen Pruhlo, Maryna Duchenko, Mariia Kulagina, Victoriia Kudria, Vashchuk Valentyna
Pages : 73-82
Doi:10.52794/hujpharm.1033112
View : 13 | Download : 2
Publication Date : 2022-06-01
Article Type : Research
Abstract :The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.Keywords : 1.2.4-triazole, antioxidant activity, in vitro method