- Genel Tıp Dergisi
- Vol: 33 Issue: 1
- Evaluation of Visual Evoked Potentials in Children with Neurofibromatosis Type 1 and Comparison With...
Evaluation of Visual Evoked Potentials in Children with Neurofibromatosis Type 1 and Comparison With Radiological Findings
Authors : Ülkühan ÖZTOPRAK, Erhan AKSOY, Nesrin CEYLAN, Ayse Secil EKSİOGLU, Deniz YÜKSEL
Pages : 113-113
Doi:10.54005/geneltip.1268084
View : 8 | Download : 4
Publication Date : 2023-02-28
Article Type : Other
Abstract :Purpose: It was aimed to examine the pattern visual evoked potentials (P-VEP) of children with neurofibromatosis type 1 (NF type 1) and to evaluate the correlation of P-VEP results with optical gliomas and unidentified bright objects (UBO) associated with NF Type 1. Materials and Methods: P-VEP and P100 latencies of 28 children including 16 (%57) boys, who were followed up with the diagnosis of NF Type 1 in the Pediatric Neurology Outpatient Clinic in the Dr. Sami Ulus Maternity and Children\'s Health and Diseases Research and Training Hospital between 2017 and 2020, with a mean age of 9.61 ± 3.7 years of age were compared with the P100 latencies of a control group consisting of 28 healthy children of similar age and gender. Results: Unidentified bright objects were found in the brain of 82% of the patients by using magnetic resonance imaging, and optic glioma was found in 21% of the patients. P100 latencies were significantly longer in the patient group than in the control group (p = 0.013, p = 0.043). Patients with optic glioma were found to have significantly longer P100 latencies than patients without optic glioma, consistent with the anatomical location of the optic glioma (p = 0.042, p = 0.025). Conclusion: With this study, it has been shown that the P-VEP test is an objective electrophysiological test that can be used in the functional assessment of visual pathways in children with NF Type 1. We think that the use of the P-VEP test in the clinical follow-up of children with NF Type 1 may be particularly useful in the early detection of optic gliomas.Keywords : Neurofibromatosis type 1, Pattern visual evoked potentials, Children