- Genel Tıp Dergisi
- Vol: 32 Issue: 4
- The Relationship Between Structural Measurements of the Corpus Callosum and Disability in Patients w...
The Relationship Between Structural Measurements of the Corpus Callosum and Disability in Patients with Multiple Sclerosis
Authors : Aysegul DEMİR, Fettah EREN, Süeda Ecem YILMAZ, Necat İSLAMOĞLU
Pages : 433-438
Doi:10.54005/geneltip.1124013
View : 18 | Download : 4
Publication Date : 2022-08-31
Article Type : Research
Abstract :Abstract Purpose: The corpus callosum (CC) is the largest commissural pathway connecting both cerebral cortices. Materials and Methods: Forty MS patients and 40 healthy controls were included in this research, which was planned as a prospective and case-control study. Disability was evaluated with the expanded disability rating scale. The number of attacks, disease duration, and MS disease subtype were determined. CC genu, truncus, splenium, and anterior-posterior diameters were measured in brain magnetic resonance imaging TSE/T1 sagittal sequence, and the corpus callosum index (CCI) was calculated using these measurements. The relationship of all these parameters with each other was examined. Results: There were 40 patients (29 females, 11 males) with a mean age of 36.47±11.14 years in the study. In the CC morphometric measurements of the patients, the genu (mean±SD) was 11.46±1.60, truncus (median, min-max) 5.29 (4.6-6.52), splenium 11.09±1.82, anterior-posterior diameter 65.20 (63.64-67.22) and CCI was determined as 0.43±0.05 millimeters. The anterior-posterior diameter was smaller in MS patients (p=0.022). A negative correlation was determined between CCI and disease duration, the number of attacks, and EDSS scores in MS patients (p<0.05; r=-0.319; r=-0.316; r=-0.349; respectively). In the severe disability group, CC splenium, AP diameter, and CCI were lower (p=0.007; p=0.020; p=0.046; respectively). Conclusion: In MS disease, the CC structure is affected, as in many central nervous system regions. The study results revealed that changes in the corpus callosum could be examined as a parameter in evaluating the disease process in MS patients. Keywords: Multiple sclerosis; corpus callosum; morphometry; disability.Keywords : Multiple sclerosis, corpus callosum, morphometry, disability