- Gazi Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
- Vol: 4 Issue: 2
- Pharmacologically Active Molecules Bearing the Pyridazinone Ring as Main Scaffold
Pharmacologically Active Molecules Bearing the Pyridazinone Ring as Main Scaffold
Authors : Zeynep Özdemir, Mehmet Abdullah Alagöz, Gülnur Arslan, Azime Berna Özçelik
Pages : 61-79
View : 22 | Download : 35
Publication Date : 2022-08-31
Article Type : Review
Abstract :Pyridazines are organic compounds in which benzene has nitrogen atoms instead of two carbon atoms. The pyridazine structure is one of the heteroaromatic rings that can be developed for drug design. Pyridazinone analogues are found in the structure of drugs with different activities. This core is of interest to medicinal chemists because of its diverse pharmacological activities. In this review, some of the antibacterial and antifungal, analgesic and anti-inflammatory, anticancer, cardiovascular and anticholinesterase compounds with pyridazinone structure are mentioned.Keywords : pyridazine, 3(2H)-pyridazinone, heterocyclic, biological activity