- Fabad Eczacılık Bilimler Dergisi
- Vol: 48 Issue: 2
- The Effect of Troxerutin Consumption on the Symptoms of Morphine Withdrawal Syndrome in Male Mice
The Effect of Troxerutin Consumption on the Symptoms of Morphine Withdrawal Syndrome in Male Mice
Authors : Ramin Ghasemi Shayan, Nasrin Hosseinzad Manie
Pages : 183-200
Doi:10.55262/fabadeczacilik.1177914
View : 55 | Download : 41
Publication Date : 2023-08-01
Article Type : Research Article
Abstract :Introduction: Chronic morphine use is associated with increased oxidative stress and inflammatory factors. Troxerutin is a natural bioflavonoid and has antioxidant and anti-inflammatory effects that could relieve morphine withdrawal syndrome. Aim: The effects of troxerutin on morphine dependence in mice Method: Troxerutin was prepared in three different doses (50, 100, and 200 mg/kg) via a normal saline solution. After examining the composition of troxerutin, the experiment was performed in five groups of 8 mice. One group received eight days of increasing doses (10, 20, 30, 40, 50, and 60 mg/kg) of morphine SC (subcutaneously) with normal saline (10 ml/kg) IP (Intraperitoneal), and one group received only normal saline and the other three groups received three different doses of troxerutin solved in normal saline as the carrier of troxerutin along with morphine. On the ninth day, withdrawal symptoms were recorded after naloxone injection and blood samples were examined for antioxidant factors. Results: The total withdrawal score in the 50 mg/kg dose of the troxerutin group with morphine was significantly lower than the morphine-saline group (p 0.05). Conclusion: Troxerutin reduces the symptoms of morphine withdrawal syndrome in a dose-dependent manner. The results of antioxidant tests declared that troxerutin would increase the level of TAC (Total Antioxidant Capacity) and decrease the level of MDA (Malondialdehyde) in the serum of mice possibly due to its antioxidant properties.Keywords : : morphine, troxerutin, withdrawal syndrome, dependence, MDA, TAC, mice