- Erciyes Üniversitesi Veteriner Fakültesi Dergisi
- Vol: 20 Issue: 1
- Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension
Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension
Authors : Tarık Mecit, Nadide Nabil Kamiloğlu, Pelin Şahin, Dinçer Erdağ, Oğuz Merhan
Pages : 30-37
Doi:10.32707/ercivet.1259252
View : 11 | Download : 3
Publication Date : 2023-04-03
Article Type : Research
Abstract :In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P<0.001). In conclusion, it is suggested that supplementation of L-carnitine and CoQ10 can be considered as a combination therapy strategy for patients prone to higher levels of oxidative stress and inflammation.Keywords : ACE inhibitörü, hipertansif, koenzim Q10, L-karnitin