- Ege Tıp Bilimleri Dergisi
- Vol: 4 Issue: 1
- The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C
The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C
Authors : Arzu ŞENOL, Zülal AŞCI TORAMAN
Pages : 14-19
Doi:10.33713/egetbd.880183
View : 14 | Download : 3
Publication Date : 2021-04-30
Article Type : Research
Abstract :Objective: Leptin plays an important role in inflammation and liver fibrogenesis in viral liver diseases. In this study, determination of serum leptin level and the effect of leptin levels on liver inflammation and fibrosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) cases were evaluated. Materials and Methods: The study groups consisted of 75 CHB, 36 CHC patients and 51 healthy subjects were included in the study as the control group. Liver biopsy specimens were scored using Ishak histological scoring system. Serum leptin levels were determined by ELISA method. Results: 39 of the chronic hepatitis B cases were female, 36 were male, 18 of the CHC cases were female, 18 were male, and 26 of the control group were female 25 one was male. Serum leptin levels were statistically significantly higher in CHB and CHC cases than in the control group (p: 0.001). However, there was no statistically significant difference in serum leptin level between CHC and CHB cases. There was no statistically significant difference between serum leptin levels and age, gender, and biochemical parameters (P> 0.05). Serum leptin levels were statistically significantly higher in patients with significant fibrosis in chronic hepatitis B and KHC patients compared to those with mild fibrosis. Conclusion: Leptin plays a role in liver inflammation and fibrosis in CHB and CHC. Leptin level indicates advanced fibrosis. In CHB and CHC patients, leptin levels can be used to evaluate the degree of advanced fibrosis and in clinical follow-up, but larger studies are needed.Keywords : Leptin, chronic hepatitis B, chronic hepatitis C