- Düzce Tıp Fakültesi Dergisi
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- Propafenone Induced Takotsubo Cardiomyopathy: A Mere Coincidence or A New Causal Relationship?
Propafenone Induced Takotsubo Cardiomyopathy: A Mere Coincidence or A New Causal Relationship?
Authors : Fahri Çakan, Adem Adar
Pages : 297-301
Doi:10.18678/dtfd.1307722
View : 54 | Download : 116
Publication Date : 2023-12-30
Article Type : Other
Abstract :Propafenone is a class 1C antiarrhythmic drug that blocks sodium channels and is used in the treatment of arrhythmia. Because of its rapid effect on terminating paroxysmal episodes of atrial fibrillation, it can be used as a pill-in-the-pocket. In patients with structural heart disease, it is less preferred due to cardiotoxic effects in long-term use. Although propafenone use is known to cause several cardiovascular side effects, the development of Takotsubo cardiomyopathy is unknown. Propafenone toxicity at standard doses is a rare condition. Propafenone plasma concentrations may increase through inhibition of cytochrome P450 2D6 and complete inhibition of 2D6 metabolism can increase propafenone levels by up to 3 to 10 times. In this case report, we aimed to present a 37-year-old female patient who developed Takotsubo cardiomyopathy and cardiogenic shock after the first dose of propafenone use and recovered with medical treatment.Keywords : Takotsubo, Propafenon, Kardiyomiyopati