- Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
- Vol: 4 Issue: 3
- The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimeste...
The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results
Authors : Nur Dokuzeylül Güngör, Tuğba Gürbüz, Aynur Erşahin
Pages : 1083-1093
Doi:10.30569/adiyamansaglik.440359
View : 38 | Download : 15
Publication Date : 2018-12-15
Article Type : Research
Abstract :Objects To compare first trimester screning serum markers free β-human chorionic gonodotropin (free β-hCG and pregnancy associated plasma protein A (PAPP-A) of blastocyst versus cleavage stage embryo transfers after assisted reproductive technologies (ART) . Methods Retrospective analysis of 123 women who conceived with ART undergone first-trimester screening between January 2017 and December 2017 at Bahçeşehir University Göztepe Medical Park Hospital IVF Unit. The age, gestational week, ultrasound markers and biochemistry markers (PAPP- A,free β-hCG) were collected. Results were considered significant when the p value was less than 0.05. Statistical Package For Social Sciences (SPSS) version 17.0 for Windows was used for statistical analysis. Results PAPP-A levels were significantly lower in day-3 (cleavage stage embryos) transfer intracytoplasmic sperm injection ( ICSI) pregnancies compared to day-5 (blastocyst stage embryos) transfer ICSI pregnancies (p<0.05). Free β-hCG levels weren’t significantly differ in two groups (p=0.371). NT was unaffected by the day of transfer (p=0.21). Also CRL wasn’t affected by the day of transfer (p=0.693). No differences appeared between day-3 and day-5 embryo transfer with respect to maternal age ,(p=0.616) weight (p=0.693) and gestational age (p=0.742) at sampling. Conclusion Today, the data on the effect of ART on the components of first trimester combined screening for chromosomal analysis are still controversial. Day-3 ICSI pregnancies had significantly lower PAPP-A levels supporting the need to appropriately adjust the combined first trimester screening (cFTS) risk algoritm. These results may be due to alterations in the placentation of ART pregnancies .Keywords : Assisted reproduction techniques, blastocyst, cleavage, first trimester screening