- Bor Dergisi
- Vol: 6 Issue: 1
- Synthesis and characterization of carborane-functionalized hyperbranched polyester for boron neutron...
Synthesis and characterization of carborane-functionalized hyperbranched polyester for boron neutron capture therapy
Authors : Gülten Özçayan, Yüksel Şahin, A. Ernur Söylemez, M. Elif Ünsal
Pages : 252-262
Doi:10.30728/boron.763317
View : 18 | Download : 9
Publication Date : 2021-03-31
Article Type : Research
Abstract :The purpose of this study is to synthesize new boron containing carrier compound for Boron Neutron Capture Therapy (BNCT) which is two-component radiation therapy method that especially is promising for the treatment of brain tumors and is being actively researched in many countries. For this research hyperbranched polyester (HBP), bifunctional p-carborane and carborane-functionalized HBP were synthesized. Dipentaerythritol was chosen as a core molecule of the HBP and esterified with dimethylol propionic acid. Observed characteristic ester bands and OH stretching band in the FTIR spectrum and the methyl & methylene peaks in the 1H NMR spectrum of HBP indicated that hyperbranched polyester synthesis was done successfully. A bifunctionalized p-carborane containing an acid group and a benzyl ether protected alcohol was prepared in three-step reactions. As a result of these reactions, a bifunctionalized p-carborane compound was produced with 60% yield. Then, the HBP was esterified with the bifunctional p-carborane. The characterization of the synthesized compounds was determined by FTIR and NMR spectra. The synthesis of carborane-functionalized HBP was confirmed by disappearance of HBP's OH groups and B-H stretching band observed in the FTIR spectrum of carborane-functionalized HBP and in addition, appearance of proton signals of HBP core, carborane linker and peripheral-protecting groups in the 1H-NMR spectrum. Finally, synthesized water-soluble carborane-containing HB carrying many boron atoms should be served as potential BNCT agents.Keywords : Bnct, boron, carborane, esterification, hyperbranced polyester