- Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
- Vol: 12 Issue: 1
- Synthesis of N-Mannich bases from 5-((4-methylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2-thiol
Synthesis of N-Mannich bases from 5-((4-methylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2-thiol
Authors : Yıldız Uygun Cebeci
Pages : 146-150
Doi:10.17798/bitlisfen.1205608
View : 6 | Download : 3
Publication Date : 2023-03-22
Article Type : Research
Abstract :Methyl (4-methylpiperazin-1-yl)acetate (2) were synthesized by the condensation of compound (1) with ethyl bromoacetate in basic media. aThe synthesis of acid hydrazide derivatives (3) was brought about as a result of the reaction between a compound (2) and hydrazine hydrate. In the absence of basic conditions, the reaction of 2-(4-methylpiperazin-1-yl)acetohydrazide (3) with carbon disulfide resulted in the formation of 5-((4-methylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2-thiol (4). aThe reactions of (4) with different primary and secondary amines in the presence of formaldehyde led to the formation of the corresponding Mannich bases (5a-f).Keywords : Mannich base, synthesis, 1, 3, 4-oxadiazole