- Medical Records
- Vol: 5 Issue: 2
- Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity
Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity
Authors : Eda Yildizhan, Burak Veli Ülger, Murat Akkuş, Ömer Faruk Katanalp, Ebru Gökalp Özkorkmaz, Ibrahim Yildizhan
Pages : 400-5
Doi:10.37990/medr.1197782
View : 12 | Download : 5
Publication Date : 2023-05-15
Article Type : Research Article
Abstract :Aim: Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, antiinflammatory and antiapoptotic effects. We objective to examine the protecting efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. Material and Methods: In ours study we used 28 male rats. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral (p.o.) for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. Results: BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. TAS and TOS grades were higher in the DM group matched to the RA+DM group. The damage scores of the DM group were higher aacording as those of the RA+DM group. Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.Keywords : Deltamethrin, rosmarinic acid, hepatotoxicity, nephrotoxicity